Proto-oncogene tyrosine-protein kinase

Non-receptor proto-oncogene tyrosine-protein kinase (NTPK) are enzymes which transfer a phosphate group from ATP to proteins. For details of Proto-oncogene tyrosine-protein kinase SRC see SRC.

3D structures of proto-oncogene tyrosine-protein kinase
Proto-oncogene tyrosine-protein kinase SRC

3lok, 3geq, 2qi8 – cNTPK SRC kinase domain (mutant) – chicken

3fj5 - cNTPK SRC SH3 domain

1f2f - cNTPK SRC SH2 domain (mutant)

1yi6 – hNTPK SRC C terminal - human

1yoj - hNTPK SRC kinase domain (mutant)

1fmk - hNTPK SRC kinase, SH2, SH3, C terminal domains

Binary complex

1p13 - cNTPK SRC SH2 domain + peptide

1f1w - cNTPK SRC SH2 domain (mutant) + phosphopeptide

3g6g, 3f6x, 3el7, 3el8, 3en4, 3en5, 3en6, 3en7, 2hwo, 2hwp - cNTPK SRC kinase domain + inhibitor

3f3v, 3f3w, 3g6h, 3f3t, 3f3u, 2qlq, 2qq7 - cNTPK SRC kinase domain (mutant) + inhibitor

3g5d - cNTPK SRC kinase domain (mutant) + cancer drug

2oiq - cNTPK SRC kinase domain + cancer drug

3dqw - cNTPK SRC kinase domain (mutant) + ATPγS

3dqx - cNTPK SRC kinase domain + ATPγS

3d7t - cNTPK SRC kinase domain + inactivator CSK (mutant)

3d7u - cNTPK SRC kinase domain + inactivator CSK

2h8h, 2bdf, 2bdj – hNTPK SRC + inhibitor – human

1yol, 1yom - hNTPK SRC kinase domain (mutant) + inhibitor

1y57 - hNTPK SRC kinase, SH2, SH3 domains + inhibitor

1ksw - hNTPK SRC kinase, SH2, SH3 domains (mutant) + benzyl ADP

1o41, 1o42, 1o43, 1o44, 1o45, 1o46, 1o47, 1o48, 1o49, 1o4a, 1o4b, 1o4c, 1o4d, 1o4e, 1o4f, 1o4g, 1o4h, 1o4j, 1o4i, 1o4k, 1o4l, 1o4m, 1o4n, 1o4o, 1o4p, 1o4q, 1o4r - hNTPK SRC SH2 domain + inhibitor

2src - hNTPK SRC kinase, SH2, SH3, C terminal domains + AMP-PNP

Proto-oncogene tyrosine-protein kinase LCK

2iim - hNTPK LCK SH3 domain

1kik, 1h92 - hNTPK LCK SH3 domain - NMR 1x27 - hNTPK LCK SH2, SH3 domains

3lck - hNTPK LCK kinase domain

Binary complex

1ijr - hNTPK LCK SH2 domain + phosphotyrosine analog

3ad4, 3ad5, 3ad6, 3kmm, 3ac1, 3ac2, 3ac3, 3ac4, 3ac5, 3ac8, 3acj, 3ack, 3kxz, 2zyb, 3byo, 1zm1, 2zm4, 3bym, 3bys, 3byu, 3b2w, 2of2, 2of4, 2ofu, 2ofv, 2og8 – hNTPK LCK kinase domain+ inhibitor

2pl0 - hNTPK LCK kinase domain + cancer drug

Proto-oncogene tyrosine-protein kinase FYN

3h0f, 3h0h, 2h0i, 3cqt - hNTPK FYN SH3 domain (mutant)

1zbj - hNTPK FYN SH3 domain – NMR 1g83 - hNTPK FYN SH2, SH3 domains (mutant)

Binary complex

2dq7 - hNTPK FYN kinase domain + antibiotic

1m27 - hNTPK FYN SH3 domain + SH2 domain protein 1A + SLAM

Proto-oncogene tyrosine-protein kinase ABL1

3eg0, 3eg2, 3eg3, 3egu - hNTPK ABL1 SH3 domain (mutant)

2fo0 - hNTPK ABL1 SH2]], SH3 domains (mutant)

1zzp - hNTPK ABL1 F-actin binding domain – NMR 1opj, 1opk, 1opl - mNTPK ABL1 kinase domain – mouse

Binary complex

3eg1, 2o88 - hNTPK ABL1 SH3 domain (mutant) + peptide

1ju5 - hNTPK ABL1 SH3 domain + CRK SH2 domain + CRK phosphopeptide - NMR 3k2m - hNTPK ABL1 SH2 domain + monobody A4

2e2b, 2hiw - hNTPK ABL1 kinase domain + inhibitor

2f4j - hNTPK ABL1 kinase domain (mutant) + inhibitor

3cs9, 2hyy, 2hz0, 2hz4, 2hzi, 2hzn, 2gqg - hNTPK ABL1 kinase domain + cancer drug

2g1t - hNTPK ABL1 kinase domain + peptide

3ik3, 1m52, 1fpu - mNTPK ABL1 kinase domain + inhibitor

1iep - mNTPK ABL1 kinase domain + cancer drug

3dk3, 3dk6, 3dk7, 2qoh, 2v7a, 2z60 - mNTPK ABL1 kinase domain (mutant) + inhibitor

Proto-oncogene tyrosine-protein kinase FER

2kk6 - hNTPK FER SH2 domain

Proto-oncogene tyrosine-protein kinase KIT

2ec8 - hNTPK KIT extracellular domain

Binary complex

3g0e, 3g0f - hNTPK KIT kinase domain (mutant) + cancer drug

2e9w, 2o26 - hNTPK KIT extracellular domain + stem cell factor

Proto-oncogene tyrosine-protein kinase FES

3bkb - hNTPK FES kinase, SH2 domains

2dcr, 1wqu - hNTPK FES SH2 domain – NMR

Binary complex

3cd3, 3cbl - hNTPK FES kinase, SH2 domains + peptide

Proto-oncogene tyrosine-protein kinase MER

2p0c - hNTPK MER kinase domain

2dbj - hNTPK MER precursor fibronectin domain – NMR

Binary complex

3bpr - hNTPK MER kinase domain + inhibitor

3brb - hNTPK MER kinase domain + ADP

Proto-oncogene tyrosine-protein kinase YES

2hda - hNTPK YES SH3 domain